Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives.
نویسندگان
چکیده
SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and selective for SRPK-1 kinase. Most of these novel compounds have drug-like properties according to experimentally determined LogP and LogS values.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 15 13 شماره
صفحات -
تاریخ انتشار 2005